Tablet



Patented F eb. 10, 11.925.

iii.

BUBBLE IBERENDES AND WILHELM GBU'TTEFIEN, OF ELBE BFELD, GERMANY, AS-

SIGNORS T FARBENFABRIKEN VOIR-M. FRIEDR. BAYER AND 00., OF LEVERK'USEN,

NEAR COLOGNE, GERMANY.

TABLET.

No Drawing.

CGH3QCOOH.OCOCH, :CH3 1 e149 Owing to its insolubility in the gastricjuice it is devoid of the irritating effect of the salicylates in thestomach. In the alkalin intestinal juices it liberates meta-cresotinicacid which shows a far less diaphoretic action than the salicylic acidliberated from acetyl-salicylic acid. Our new tablets con-- tainacetyl-ineta-cresotinic acid and other ingredients such as starch.

In order that the tablets may be used di-v rectly, the tablets of thepresent invention are advantageously prepared with a definite amount ofacetyl-meta-cresotinic acid and we have found that tablets containing0.5 gram are particularly valuable. Not only is easy and accurate dosagethereby made possible, but such tablets contain what we have found to bea proper and normal amount of the acetyl-meta cresotinic acid. Moreoverby breaking such. tablets in half, which is made possible by their hardbut brittle structure, doses of 0.25 gram are readily obtained, whilefor larger doses 2 or 3 tablets can be used. The tablets are readilydisintegrated in water, either Warm or cold, and are advantageously sodisintegrated in water, either warm or cold, and are advantageously sodisintegrated before taking.

We have now made the surprising dis- Application filed June 15, 1922.Serial No. 568,627.

covery that the acetyl-meta-cresotinic acid has the above. statedtherapeutically valuable properties and that this material isparticularly valuable as a remedy.- The material itself, theacetyl-meta-cresotinic acid, has been known as a chemical product. Theuse of thismaterial as a therapeutic compound has never heretofore beenproposed. The acetyl-meta-cresotinic acid is prepared by treating e.g.250 parts by weight of meta-cresotinic acid with 400 parts by Weight ofacetic acid anhydride and 2 parts by weight of pyridine. This mixture isallowed to stay at the ordinary temperature. After some time the productseparates. It is filtered mi and crystallized from benzene. It melts atabout 139 C.

We claim 1. As a new article of manufacture and an antipyretic,antineura'lgic tablet comprising" acetyl-meta-cresotinic acid.

2. As a new article of manufacture and an antipyretic, antineuralgictablet containing about 0.5 gram of acetyl-meta-cresotinic acid.

3. As a new article of manufacture, a

hard compressed whitish antipyretic and antineuralgic tablet comprisingacetyl-metacresot-inic acid which disintegrates in water.

4. As a new article of manufacture and an antipyretic, antineuralgictablet comprising acetyl-meta-cresotinic acid which is tasteless anddisintegrates in water.

5. As a new article of manufacture, a

hard brittle antipyretic and antineuralgic tablet acid.

6. As a new article of manufacture, a hard brittle whitish antipyreticand antineucomprising acetyl-meta-cresotinic ralgic tablet containingabout 0.5 gram of acetyl-meta-cresotinic acid, said tablet beingsubstantially free from foreign substances, and readily disintegratingin water.

In testimony whereof we have hereunto set our hands.

RUDOLF BERENDES. WILHELM GRUTTEFIEN.

